BioPro+ by BioProtein Technology
A sublingual velvet-antler growth-factor formula marketed as a drug-free HGH alternative - one of the most-hyped, most-debated supplements in the optimizer world.
BioPro+ is a sublingual liquid built on velvet-antler growth-factor extract, marketed as a drug-free, non-synthetic alternative to prescription growth-hormone peptides. It is one of the most-hyped supplements in the longevity-optimizer world, and one of the most-debated.
Here is what it actually is. BioPro+ is a once-daily sublingual blend (about 211mg) built around a deer velvet-antler extract the company describes as a source of bioidentical growth factors, including IGF-1, plus a botanical supporting cast: Tribulus, Shilajit, Lycium (goji) berry, and aloe. You shake it, hold it under your tongue for roughly 90 seconds, then swallow. The pitch is that those growth factors support recovery, lean mass, energy, sleep, and hormonal balance the way your body's own growth signals do, without a prescription and without injectable peptides.
Now the honest part, because that is the whole point of this site. The marketing leans hard on the idea that BioPro+ raises your HGH or IGF-1, and the evidence for that specific claim is thin. IGF-1 is a large peptide, and intact absorption through the mouth or gut is biochemically questionable, because proteins like this are generally broken down before they reach circulation. Controlled trials on velvet antler in athletes have mostly found no measurable change in IGF-1 or performance, and there is no published randomized trial on the BioPro+ formula itself. One ingredient, Lycium, has small human studies on metabolic rate. The rest of the enthusiasm is practitioner endorsement and user testimonial, not clinical proof.
So why does it have a following at $249 a month? Because some users genuinely report better energy, recovery, and sleep, and because it scratches a real itch: a legal, drug-free, needle-free option for people who want the growth-hormone thesis without a TRT clinic or grey-market peptides. That is a legitimate reason to try it. Just go in clear-eyed: this is a subjective experiment you run on yourself for a month or two, not a proven intervention. The statements have not been evaluated by the FDA, and the product is not intended to diagnose, treat, cure, or prevent any disease.
Optimizers who want a legal, drug-free, needle-free alternative to prescription growth-hormone peptides, and who are comfortable paying a premium to run a try-it-and-track-how-you-feel experiment.
You want RCT-backed mechanisms. The human evidence that sublingual velvet-antler growth factors raise HGH or IGF-1 is weak, and IGF-1 oral bioavailability is questionable. At $249/mo, NAD precursors, creatine, and protein deliver far more proven value per dollar.
Specifications
Most often compared with
Where this fits
BioProtein Technology BioPro+ Growth Factor Sublingual cross-shops across several editorial surfaces - the full brand catalog, the buyer-intent tags this item carries, the price band it qualifies for, and any execution playbook that uses it.
BioProtein Technology BioPro+ Growth Factor Sublingual - buyer FAQ
Does BioPro+ actually raise your HGH or IGF-1?
That is the central marketing claim, and it is the one to be skeptical of. IGF-1 is a large peptide, and intact absorption through sublingual or oral routes is biochemically questionable, since it is typically broken down before reaching the bloodstream. Controlled trials on velvet antler (its core ingredient) in athletes have generally shown no significant change in IGF-1 or performance, and there is no published randomized trial on the BioPro+ formula itself. Most support is practitioner endorsement and user testimonial, not clinical proof. Treat the HGH-boost framing as marketing, not established fact.
What is actually in it?
A roughly 211mg sublingual blend built on deer velvet-antler extract (marketed as a source of growth factors including IGF-1), plus Tribulus, Shilajit, Lycium (goji) berry, and aloe. It is taken once each morning: shaken, held under the tongue about 90 seconds, then swallowed. The statements have not been evaluated by the FDA, and the product is not intended to diagnose, treat, cure, or prevent any disease.
How much does BioPro+ cost?
About $249.98/month on subscribe-and-save, $299.99 as a one-time purchase, or $899 for a 4-month bundle, with a 30-day return window. It sits at the very top of the supplement price range, which is why it is worth treating as a deliberate experiment rather than a default buy.
Is BioPro+ worth it?
If you want a legal, drug-free, needle-free way to test the growth-hormone thesis and you will judge it honestly by how you feel over one to two months, some users report better energy, recovery, and sleep, so it can be a reasonable experiment. If you want proven, mechanism-backed longevity spend, NAD precursors, creatine, protein, and sleep fundamentals have far stronger evidence per dollar. Buy it as an experiment, not a guarantee.
BioPro+ by BioProtein Technology
$250–$300/mo · Verified 2026-06-05
Shop BioProtein Technology →