SUPPLEMENTS · 54 ITEMS

Foundational supplements with real science

Momentous, AG1, Thorne, LMNT, Timeline. 58 longevity supplements reviewed, NSF certification checked per SKU, every price verified against the brand store.

TIER

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DEEP REVIEW

Timeline·Supplements

Mitopure

The supplement that single-handedly created the Urolithin A category - a pomegranate metabolite most people can't produce on their own, delivered in a research-backed 500mg dose at $100/month.

Tru Niagen·Supplements

Tru Niagen (300mg NIAGEN)

The NAD+ precursor that came with the patent and the published trials - ChromaDex's NIAGEN is the most-studied NR on the market, sold direct as Tru Niagen.

NOVOS Core

The longevity stack with a Harvard / MIT scientific board behind it - twelve ingredients in one daily packet, designed to address what the team calls "the 12 hallmarks of aging."

Wonderfeel·Supplements

Youngr NMN

900mg of NMN per daily serving - 2-3x what most NMN brands deliver - plus a co-factor stack (resveratrol, ergothioneine, hyaluronic acid) the prestige tier doesn't bundle. Formulated by a Harvard MD, Dr. Andrew Salzman. Not the cheapest NMN, but the densest.

TruLab Peptides·Supplements

Research Peptides Catalog

A research-peptide catalog with the rarest combination in the category - third-party mass-spec verification published per lot, public CoAs, and an actually navigable storefront.

BiOptimizers·Supplements

Magnesium Breakthrough

The magnesium that turned the category from "buy whatever's on the shelf" into "wait, which form?" - seven types in one capsule, from the brand that built its name on the question.

Cymbiotika·Supplements

Liposomal Glutathione

The liposomal glutathione that takes encapsulation seriously - phosphatidylcholine carrier, no preservatives, single-serve packets, and a price that lands closer to legacy mid-tier brands than to Quicksilver Scientific.

Approved Science·Supplements

Clinically-Backed Supplements

Condition-specific clinical formulations (Joint, Brain, Immune, Sleep, Gut, Vision - 20+ targeted products) at 50% the price-per-serving of Thorne or Pure Encapsulations. Vegan, third-party tested, manufactured in US cGMP facilities, money-back guarantee. Same clinical-grade quality the prestige brands charge $50-80 per bottle for.

SuperAkki·Supplements

Next-Gen Akkermansia (Akk11 + Bioferrin)

SuperAkki and Pendulum sell the same organism in opposite forms. Pendulum sells live Akkermansia muciniphila; SuperAkki sells it pasteurized, as a postbiotic, which is why this one is shelf-stable and that one is not.

Liposomal NAD+

Solaray is one of the older names in US supplements (founded 1973), and its Liposomal NAD+ brings the marquee longevity molecule into a value-priced liposomal cap at $42.50, well under the boutique NAD+ brands.

Collagen PRO

Nume's Collagen PRO is a grass-fed, hydrolyzed Type I and III collagen powder at $79.95, the anchor of a broad daily-wellness supplement line.

Sleep Gummies (PeptiSleep)

Brik Sleep Gummies take a genuinely different route to melatonin-free sleep support: 250 mg of PeptiSleep, a plant-derived peptide complex licensed from AI-biotech ingredient company Nuritas, in one nightly gummy at $49.99 for a 30-night pouch, verified July 2026.

Mind Lab Pro·Supplements

v4.0 Universal Nootropic

Mind Lab Pro v4.0 is the fully disclosed nootropic: 11 ingredients, every dose on the label, zero caffeine. At $62.10 to $69 a month, verified July 2026, it charges premium money for that transparency.

Performance Lab·Supplements

NutriGenesis Multi for Men

Performance Lab's NutriGenesis Multi for Men is the cultured-nutrient alternative to the drugstore multivitamin: 24 essential vitamins and minerals grown in live cultures, delivered in vegan pullulan capsules, at $49 for a 30-day supply, verified July 2026.

Sprout Living·Supplements

Epic Protein

Epic Protein puts 20g of organic plant protein in a 38g scoop with no gums, fillers, or flavoring agents, and the 1lb Vanilla Lucuma bag costs $34.95, verified July 2026. The ingredient list is the pitch.

Hydration + Energy Drink Mix

One stick, three jobs: electrolytes, 100 mg of organic caffeine, and a focus stack. At $58 for 30 servings, verified July 2026, Vibras prices itself against your hydration mix and your pre-workout at the same time.

Liquid I.V.·Supplements

Hydration Multiplier

Liquid I.V. Hydration Multiplier is the electrolyte stick pack you have seen everywhere: one packet in 16 ounces of water delivers 500mg of sodium and 370mg of potassium. At $24.99 for a 16-pack, it is the entry-level, mass-market option in the hydration category.

Akkermansia

Pendulum Akkermansia is a single-strain probiotic built around Akkermansia muciniphila, a gut bacterium tied to the mucus lining of the intestine. Pendulum states it is the only live Akkermansia muciniphila probiotic clinically studied to fortify the gut lining, a positioning claim we report as brand-stated.

:rise Cacao Starter Kit

MUD\WTR is the coffee alternative that actually caught on: a USDA-organic blend of cacao, masala chai spices, and adaptogenic mushrooms with roughly one-seventh the caffeine of a cup of coffee, aimed at people who want a morning ritual without the jitters-and-crash cycle.

Terra Mare·Supplements

Morning Restore

Terra Mare is the women's-health supplement line founded by actress Marisa Tomei, and Morning Restore is its flagship: a one-scoop daily powder that stacks marine collagen, seven probiotic strains, six organic mushrooms, and a greens blend aimed at women's healthy aging.

1MD Nutrition·Supplements

Complete Probiotics Platinum

1MD's Complete Probiotics Platinum packs 51 billion CFU across 11 strains plus Nutraflora prebiotic fiber into a single daily capsule. At $49 for a 30-day bottle it sits mid-market, and 1MD frames it as a 12-week microbiota-restoration course rather than a quick fix.

NMN Capsules 500mg

NMN capsules delivering 500mg of the NAD+ precursor per serving, third-party lab tested batch by batch.

Smart Fuel·Supplements

Motivation: Encapsulated

A focus-and-drive capsule as Smart Fuel debut product, for readers who want a nootropic-style pick from an emerging brand.

Complete Optimization for Men

A pre-dosed daily supplement system built for men who want their whole optimization stack in one pack.

Secret Element·Supplements

Citrus Bergamot

A standardized citrus bergamot polyphenol supplement, third-party tested and made in a cGMP USA facility.

Nouro

A daily brain-health capsule stack formulated with Alpha GPC, paraxanthine, taurine and other studied compounds.

1st Phorm·Supplements

Opti-Greens 50 (Natural Berry)

The greens powder people actually finish, because it was engineered for gut comfort and flavor first.

WishGarden Herbs·Supplements

Kick-Ass Immune, Activator

WishGarden has been hand-crafting liquid herbal extracts in Colorado since 1979, and Kick-Ass Immune is the bottle that put the brand on the map. It is a no-frills dropper tincture, not a capsule or gummy.

Troomy Nootropics·Supplements

Focus Lion's Mane Gummies

Lion's Mane is the most popular functional mushroom in the nootropic world, and a gummy is the format most likely to actually get taken daily. Troomy Focus delivers 800mg per serving in a pectin gummy, and it is the brand's most-reviewed product.

Creatine Monohydrate Gummies

Creatine monohydrate is one of the best-studied supplements there is. The catch is daily adherence to a powder. Arq8 puts 5g into four sugar-free gummies, trading a price premium for a format you will actually keep taking.

Creatine

Creatine monohydrate is the rare supplement where the evidence is not in question. The only real question is whether the powder in the tub is clean, and that is where Thorne earns its place.

Magnesium Bisglycinate

Magnesium is one of the few supplements with a genuine population-level case, but the form is everything. Thorne uses the chelated bisglycinate form most people actually tolerate.

Vitamin D + K2 Liquid

Vitamin D and K2 are often taken together for a simple reason, and Thorne packs both into a liquid that sidesteps the main annoyance of D supplements: swallowing yet another softgel.

FullDissolve Nano-Creatine Monohydrate

Creatine monohydrate works; the classic complaint is the grit at the bottom of the glass. Arq8 mills it to a nano particle so it actually dissolves.

BioProtein Technology·Supplements

BioPro+ Growth Factor Sublingual

BioPro+ is a sublingual liquid built on velvet-antler growth-factor extract, marketed as a drug-free, non-synthetic alternative to prescription growth-hormone peptides. It is one of the most-hyped supplements in the longevity-optimizer world, and one of the most-debated.

The Aeternum Company·Supplements

Longevity Molecule Range (NMN, Urolithin A, Fisetin, GlyNAC, TND1128)

The rare longevity supplement brand that carries the entire next-gen molecule shelf - Urolithin A, Fisetin, GlyNAC, NMN, TND1128 - à la carte, instead of charging single-molecule-brand prices for one of them.

Exoceuticals·Supplements

EXO PLUS Anti-Aging Cream

The cellular-signaling biotech that turned exosomes from clinical-research curiosity into a daily anti-aging cream, and the rare longevity-skincare product where the mechanism is actually published, not just brand copy.

CorneaCare·Supplements

Rise Eyelid Wipes + Eye Vitamins

The intervention 16 million Americans need and no one in the longevity stack talks about: clinical eyelid hygiene.

Full Spectrum CBD Gummies 3600mg (120mg/gummy)

The CBD brand that earns the longevity-stack slot the Amazon-influencer gummies don't.

Neurogan Health·Supplements

NMN Capsules 500MG

The "Clinically Dosed, Not Dusted" longevity brand, peer-reviewed dose matching across the whole longevity-supplement stack.

NAD+ Glow Up Set

The first brand to merchandise NAD+ as a skin-longevity vertical, and the one Dr. Lamees Hamdan actually formulated.

The ERLY Essentials

Skincare for the people who tried Drunk Elephant and woke up with a rash. Dermatologist-founded for sensitive, reactive, and rosacea-prone skin - hypoallergenic, fragrance-free, mostly under $50 per product. Built for the buyers prestige brands quietly aggravate.

InVite Health·Supplements

Vitamin D3 1000 IU (90-day supply)

A pharmacist-formulated Vitamin D3 from a US-manufactured supplement retailer with 30+ years of clinical credibility - and the most foundational longevity supplement in any stack at under $25 for a 90-day supply.

EcoWise Wellness·Supplements

Creatine HCl Gummies

Creatine in gummy form sounds like a marketing gimmick - until you realize compliance is the entire game with creatine, and a daily gummy beats a daily scoop of monohydrate sitting in a drawer.

Genuine Purity·Supplements

Liposomal NMN

NMN wrapped in phospholipid bubbles built to survive your gastric acid - the delivery technology that lets a 250mg liposomal dose match what 500-1500mg of standard NMN powder delivers to your bloodstream. Doctor-formulated, third-party tested, 30-day money-back guarantee.

Renue by Science·Supplements

Liposomal NMN + NAD+ Patches

A premium NMN brand competing on delivery format rather than dose - liposomal, sublingual, and patch options engineered to bypass first-pass metabolism.

Renue Blue·Supplements

Nanoliposome Skin Longevity Stack

Renue by Science's sister brand - same nanoliposome delivery science the parent company applies to internal NMN, now applied to topical skin longevity.

Goodness Lover·Supplements

Gut Health Platform

A nutritionist + advocate-founded gut-health platform that pairs targeted formulations with structured protocols - the right pick when "the gut is the foundation" is more than a slogan.

nutriEffect·Supplements

Performance & Longevity Supplements

An Italian premium-supplement brand bringing EU clean-formulation standards to the energy + focus + longevity stack - alternative to the US-dominated supplement-affiliate market.

NanoNerds·Supplements

Nordic Magnesium Stack

A Scandinavian-design magnesium brand bringing Nordic clean-formulation aesthetics to the supplement category.

Momentous·Supplements

Creatine Monohydrate

The boring supplement with the largest body of research - and the brand most longevity clinicians actually recommend.

AG1 Foundational Nutrition

The greens powder that became a category - premium-priced and worth understanding before buying.

Basic Nutrients 2/Day

The multivitamin clinicians actually recommend - Mayo Clinic partner, methylated B vitamins, no junk.

Recharge Electrolyte Mix

The electrolyte mix that became standard for low-carb, fasted training, and post-sauna rehydration.

Buyer guides

How to choose in this category, with verified prices and honest trade-offs.

Best Multivitamin Under $50

Practitioner-grade daily coverage on a budget.

Best Thorne Supplements

The practitioner-grade lineup, ranked.

Is Thorne Worth It?

NSF Certified for Sport and third-party testing, explained.

BioPro+ PM Review

The nighttime formula for sleep and recovery.

BioPro+ vs TRT & Peptides

An honest comparison of the options.

Natural Alternative to TRT & HGH

Needle-free options, honestly assessed.

Perimenopause Support

What actually helps, and where a supplement fits.

Hormone Support for Shift Workers

The honest playbook for 12-hour rotations.

Best NMN Supplements

Wonderfeel vs Renue vs Genuine Purity, plus NR alternatives.

Best Gut Health Supplements

Microbiome picks, probiotic vs prebiotic.

Frequently asked

Supplements buyer FAQ

What supplements should I actually take for longevity?

The high-evidence foundational stack: creatine monohydrate (most-studied performance + cognitive supplement), vitamin D + K2 (especially in low-sun latitudes), magnesium (any of the 7 forms BiOptimizers covers), omega-3, and a clinician-vetted multivitamin like Thorne Basic Nutrients 2/Day. Beyond foundational, evidence drops sharply - NMN, urolithin A, and niacin precursors have promising-but-incomplete human data. Always run labs first and supplement based on actual deficiencies, not protocol-stack mimicry.

AG1 vs Thorne - is it worth the premium?

AG1 ($79-99/mo subscription) is a comprehensive greens powder with 75+ ingredients. Thorne Basic Nutrients 2/Day ($35) is a focused multivitamin covering the same essential vitamin/mineral panel as AG1. Thorne is NSF Certified for Sport (banned-substance tested); AG1 isn't. For pure cost-effectiveness on the multi/mineral component, Thorne wins by a wide margin. For the convenience + adaptogen + greens layer, AG1's premium has a real consumer audience. Most clinicians we know prefer Thorne or Momentous for the foundational tier.

Are NAD+ precursors (NMN, NR) actually worth taking?

NMN and NR (Tru Niagen) are the most-marketed longevity supplements after the David Sinclair work, but the human clinical evidence is genuinely incomplete. Cell-line and animal data show NAD+ levels increase with supplementation; clinical outcomes (lifespan, healthspan markers) in humans are still being studied. The honest framing: NMN and NR are reasonable bets on emerging science, not proven longevity interventions. If budget allows, they fit in a longevity stack; if budget is tight, the foundational stack (creatine, vit D, omega-3, magnesium) has stronger evidence per dollar.

Should I bother with the Bryan Johnson Blueprint stack?

Blueprint ($354/mo) is the most comprehensive longevity supplement bundle on the market - 12+ products, 100+ ingredients, designed by Bryan Johnson's team and tracked across his own biomarkers. The case for: it's the most-tested single stack in the category by a single user. The case against: Bryan Johnson is one person, and what works for his physiology may not transfer to yours. For buyers wanting a turnkey premium stack and the brand-experience component, Blueprint delivers. For evidence-per-dollar, the foundational stack from Thorne + Momentous + LMNT covers 80% of the practical benefit at 25% of the cost.

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