Omne Diem Histamine Digest, the 30,000 HDU DAO Enzyme
A diamine oxidase (DAO) digestive enzyme at one of the highest stated potencies sold direct, 30,000 HDU per serving, from $55.95.
The highest-potency DAO enzyme in the direct-to-consumer aisle.
Price: $55.95–$87.95 · Verified: 2026-08-05
The highest-potency DAO enzyme in the direct-to-consumer aisle.
Diamine oxidase is the enzyme the body uses to break down histamine from food, and Omne Diem's Histamine Digest supplies it from porcine kidney at 30,000 HDU per serving, among the highest stated potencies sold direct to consumers. The mechanism is a digestive one: taken before a meal, supplemental DAO works in the gut on dietary histamine. That biochemical description is where our claims stop. The brand's page goes much further, into symptom relief and "clinically tested" language with no study cited, and we do not repeat any of it; if the research matters to you, discuss DAO supplementation with a clinician who knows the histamine-intolerance literature. What earns the card is the formulation fact: for anyone whose clinician has suggested DAO, this is the potency ceiling of the category, with a subscription that brings the 60-count to $50.36.
People already working with a clinician on dietary histamine who want the highest-dose DAO enzyme available without a prescription.
You are self-diagnosing histamine intolerance; the honest first step is a clinician, not a $56 bottle, and the brand's symptom claims are uncited.
Specifications
Where this fits
Omne Diem Histamine Digest 30,000 HDU cross-shops across several editorial surfaces on this site: the full brand catalog and the price band it qualifies for.
Omne Diem Histamine Digest 30,000 HDU - buyer FAQ
How much does Histamine Digest 30,000 HDU cost?
It is $55.95 for 60 capsules or $87.95 for 120, verified August 5, 2026 from the brand's own store data. The subscription drops those to $50.36 and $79.16 per delivery. The 120-count works out meaningfully cheaper per capsule for anyone using it with every meal.
What does a DAO enzyme actually do?
Diamine oxidase is the enzyme that breaks down histamine present in food. Supplemental DAO, taken shortly before eating, acts on dietary histamine in the digestive tract. It is not an antihistamine drug and this entry makes no claims about symptoms; that conversation belongs with a clinician.
Is 30,000 HDU a high dose?
Yes, relative to the category: most DAO supplements sell at 10,000 to 20,000 HDU per serving, so 30,000 is among the highest stated potencies sold direct to consumers, and the same brand sells a PureMAX version at 40,000. HDU figures are the manufacturers' own stated activity units.
Does it work for histamine intolerance?
We do not make that claim, and notably the brand's page says "clinically tested" without citing any study, so there is nothing for us to attribute. The honest position: the enzyme's digestive mechanism is established biochemistry, the supplement's clinical benefit is a question for your clinician and the published literature.
Has Lifespan Vault tested this product?
No. This entry is built from the brand's product data and page, verified August 5, 2026. We report the formulation facts, the potency as stated by the manufacturer, and the prices we confirmed; every performance and symptom claim on the brand's page remains theirs, not ours.
Omne Diem Histamine Digest, the 30,000 HDU DAO Enzyme
$55.95–$87.95 · Verified 2026-08-05
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