Six items that address the predictable GLP-1 side-effect cluster (nausea, constipation, electrolyte drift, muscle loss, sleep disruption) plus the foundational support most prescribing platforms skip. Built for buyers on semaglutide or tirzepatide who want the protocol piece their telehealth provider does not bundle.
GLP-1 medications work, but the side-effect profile is what makes users discontinue. The published discontinuation rate at 12 months is 30-50% across real-world studies - and most discontinuation is not lack of efficacy. It is nausea, constipation, fatigue, and the gnawing concern about muscle loss. Every one of those is addressable with foundational protocol pieces that the prescribing pharmacy never sells you.
This stack assembles those pieces. The bmiMD telehealth platform anchors the prescription side (compounded semaglutide / tirzepatide at the dose tier you actually need, with monthly clinician oversight). The supplement layer addresses the predictable physiology: LMNT for the electrolyte drift you get from reduced food intake, BiOptimizers Magnesium for the constipation pattern most GLP-1 users hit by week 3, the Goodness Lover gut stack for microbiome support during the reduced-feeding window, Momentous Creatine to defend lean mass through the rapid weight loss, and the Mosaic weighted blanket because sleep disruption is the most underdiagnosed GLP-1 side effect and the cheapest intervention to test.
The order matters. Start the telehealth + electrolytes + magnesium on day 1. Add creatine in week 2 once the GI side-effects stabilize. Layer the gut stack and blanket in month 2 once you know what your maintenance dose looks like. Total ~$300-650 for the first 90 days depending on protocol tier.
The stack
GLP-1 Telehealth (Semaglutide / Tirzepatide)
Why it's in this stack: The prescription anchor. Compounded semaglutide / tirzepatide via telehealth at meaningfully lower cost than retail brand-name. Monthly physician oversight included. The right baseline for buyers who want clinical access without the brand-name premium.
Recharge Electrolyte Mix
Why it's in this stack: GLP-1s reduce food intake by 30-50% in the first 60 days, which collapses sodium + potassium intake below maintenance for most users. LMNT at 1000mg sodium per stick is the single most-effective intervention for the fatigue + brain-fog cluster that hits in week 2-4.
Magnesium Breakthrough
Why it's in this stack: Constipation is the most-reported GLP-1 side effect by week 3. Magnesium glycinate + citrate addresses both the smooth-muscle motility issue and the sleep-quality decline most users notice in the first month. BiOptimizers blends 7 forms for broader coverage.
Creatine Monohydrate
Why it's in this stack: 25-40% of GLP-1 weight loss is lean mass without intervention. Creatine monohydrate at 5g/day is the highest-evidence intervention to defend muscle through rapid weight loss. Start at 3g/day for the first week to test GI tolerance (GLP-1 users have heightened sensitivity), ramp to 5g if no issues.
Gut Health Platform
Why it's in this stack: Reduced feeding windows shift microbiome composition - the published GLP-1 literature shows meaningful gut-flora changes by month 2. The Goodness Lover stack provides pre/probiotic + prebiotic fiber support during the transition. Layer in at month 2 once your eating pattern stabilizes.
Weighted Blanket
Why it's in this stack: Sleep disruption is the most underdiagnosed GLP-1 side effect - elevated cortisol + leptin shifts in the first 60 days regularly fragment deep sleep. Weighted blankets reduce sleep onset latency by ~30% in published trials. Cheapest intervention to test before considering pharmaceutical sleep aids.
Day 1: Start bmiMD + LMNT + BiOptimizers Magnesium. Week 2: Add Momentous Creatine (start at 3g/day for first week to test GI tolerance, ramp to 5g if no issues). Month 2: Layer Goodness Lover gut stack + Mosaic weighted blanket. Re-evaluate the full stack at month 3 with your clinician - some items become optional at maintenance dose.
Other curated stacks
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